Isotretinoin powder Raw Materials CAS 4759-48-2

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Uses and synthesis of Isotretinoin powder

Isotretinoin, also known as isotretinoic acid, 13-cis-retinoic acid, trade name Thale, chemical name 3, 7dimethyl-9-{2,6, 6trimethyl-1-cyclohexene-1-monyl} -2-cis-4-trans-6-trans-8-trans-nonanotetraenoic acid. This drug is effective orally for nodular cysts and aggregators and is the first choice for severe acne or cicatricial acne that does not respond well to antibiotics. Isotretinoin powder is effective in the treatment of diseases such as skin disease, tumor and recurrent respiratory tract infection in children, and has a good prospect in clinical application.

Applications/Functions of Isotretinoin powder

• Isotretinoin powder is A class of vitamin A drug, which can strongly and quickly inhibit the proliferation and differentiation of skin gland cells and is highly effective in treating severe ganglion cystic acne. Isotretinoin was well absorbed in gastrointestinal tract, but local administration was ineffective. It can also be used for severe acne, cystic acne and gathering acne that are ineffective in the treatment of other drugs. It also has certain effect on skin diseases such as rosacea, ichthyosis, follicular keratosis and pityriasis rufuropilaris.
• Isotretinoin is used for severe acne, etc.
• Isotretinoin antikeratosis.
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Physicochemical Property of Isotretinoin powder

Yellow or orange-red crystalline powder or crystal, insoluble in water, slightly soluble in ethanol, very slightly soluble in ether, and soluble in chloroform.

Production methodprocess of Isotretinoin powder

After reacting with ethyl magnesium chloride, β-ionone reacts with triphenylphosphine to form triphenyl ester salt, and then reacts with cyclopentenone derivatives to form isotretinoic acid and its 8Z isomer. The 8Z isomer was separated and isomerized to Isotretinoin by palladium nitrate.

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