Hydrochlorothiazide powder Raw Materials CAS 58-93-5

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Uses and synthesis of Hydrochlorothiazide powder

Hydrochlorothiazide white crystalline powder, odorless, slightly bitter taste. Insoluble in water or chloroform, soluble in acetone, slightly soluble in ethanol, soluble in sodium hydroxide solution, but easily hydrolyzed. Hydrochlorothiazide powder is a diuretic and antihypertensive drug. It is mainly suitable for cardiogenic edema, hepatogenic edema and renal edema

Applications/Functions of Hydrochlorothiazide powder

• Hydrochlorothiazide powder is a typical representative of effective diuretics in thiazines, and ranked first in the sales of drugs in the United States in 1985. Because it is easy to take, has a medium effect, and is suitable for various edema, it is the most common clinical adverse reaction due to potassium drainage, and potassium salt needs to be added when applied.
• Hydrochlorothiazide mainly inhibits the reabsorption of Na+ and Cl- at the proximal end of the distal tubule, which increases the excretion of sodium chloride by the kidney and produces diuretic effect, and is a medium effect diuretic. Hydrochlorothiazide has antihypertensive effect, which can be enhanced when combined with Li's patch, antihypertensive Shen patch or Apociname. This product also has antidiuretic effect and can be used to treat diabetes insipidus
• A carbonic anhydrase inhibitor.

Physicochemical Property of Hydrochlorothiazide powder

Hydrochlorothiazide white crystalline powder. Soluble point 273-275℃, soluble in acetone, slightly soluble in alcohol, insoluble in water, chloroform, ether, soluble in sodium hydroxide solution, but easy to hydrolysis. It tastes slightly bitter.

Production methodprocess of Hydrochlorothiazide powder

Hydrochlorothiazide powder was prepared from m-chloroaniline by chlorosulfonation to 5-chloro-2, 4-chlorosulfonanilide, then by ammonia reaction to 5-chloro-2, 4-aminosulfonanilide, and finally by distortion of formaldehyde.

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