Best Price CAC 16009-13-5 Hemin 95% Hemin Powder

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Uses and synthesis of Hemin powder

Hemin powder is a metal porphyrin compound with relatively simple structure, formed by the complexation of a molecule of ferrous and protoporphyrin. It is a group substitute of natural heme in vitro, and its chemical properties are similar to those of heme. Then Hemin (also known as iron porphyrin, heme chloride, hemin) was extracted from pig and cow blood and recognized by modern medicine as a biological iron source with high absorption rate and good effect in preventing and treating iron deficiency anemia. It has no iron odor and does not irritate the gastrointestinal tract. Hemin is the preferred raw material for the production of iron-supplementing foods, pharmaceuticals, health care products and cosmetics.

The main medical use of heme is in the treatment of acute intermittent porphyria (AIP) and some other forms of acute hepatic porphyria. These diseases are caused by defects in certain enzymes in the body's heme production pathway, which leads to the accumulation of toxic precursors in the body, causing neurologic, abdominal, and other symptoms.

Applications and Functions of Hemin powder

1. In the food industry, Hemin powder can replace the hair color agent nitrite and synthetic pigment in meat products. In the pharmaceutical industry, heme can be used as a semi-synthetic bilirubin raw material, and can be used to prepare anti-cancer drugs. In clinical practice, heme can be made into heme iron supplement.
2. Nutritional supplement (iron fortification agent), extracted from pig blood, recognized in modern medicine to prevent iron deficiency anemia, high absorption rate, good effect down biological iron source, no iron smell, does not stimulate the stomach. Hemin is the preferred raw material for the production of natural iron-supplementing foods, pharmaceuticals, health products and cosmetics.
3. Biochemical research; Hemin is used as a stain for blood tests. For the preparation of hematoporphyrin hydrochloride

Mechanism of action of Hemin powder

Exogenously administered heme inhibits the activity of aminolevulinic acid synthase (ALA synthase) in the liver. ALA synthase is the first rate-limiting enzyme in the porphyrin synthesis pathway. By inhibiting this enzyme, heme reduces the production of toxic porphyrin precursors, thereby alleviating the symptoms of acute porphyria attacks.

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