2-iodo-1-p-tolyl-propan-1-one powder Raw Materials CAS 236117-38-7

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Uses and synthesis of 2-iodo-1-p-tolyl-propan-1-one powder

2-iodo-1-p-tolyl-propan-1-one powder, 2-iodo-1-p-tolyl-propan-1-one CAS 236117-38-7, 2-iodo-1-p-tolyl-propan-1-one Raw Materials

Applications / Functions of 2-iodo-1-p-tolyl-propan-1-one powder

2-iodo-1-p-tolyl-propan-1-one Raw Materials are used as organic and pharmaceutical intermediates.

‌1. Chemical synthesis applications‌
‌Pharmaceutical intermediates‌: commonly used in the synthesis of anti-tumor, antibacterial and other drug active molecules as key structural modification reagents.

‌Functional material preparation‌: used as a halogen functionalization reagent in organic optoelectronic materials or polymer modification.

‌2. Reaction characteristics‌
‌Active site‌: The α-iodine ketone structure makes it easy to participate in coupling, substitution and other reactions, and is suitable for the construction of complex organic skeletons.

‌3. Other potential applications‌
‌Research applications‌: may be used as a probe or marker in metal organic chemistry research

Could you provide the detailed synthesis steps for this compound?

‌Starting material‌:
Using ‌4-methylacetophenone (p-tolyl methyl ketone)‌ as the starting material, the iodine atom is introduced by halogenation reaction.

‌Key steps‌:
‌α-halogenation reaction‌: Under alkaline conditions (such as NaOH/EtOH), it reacts with iodine (I₂) or iodination reagents (such as NIS) to generate α-iodinated products.

‌Purification‌: Isolate the target compound by crystallization or column chromatography.

‌Notes‌:
The reaction temperature needs to be controlled (0–5℃) to avoid side reactions.
The iodination reagent may need to be in excess to ensure conversion rate
 

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