Related Attributes
Product details
Atomoxetine hydrochloride powder is a white or light white solid, soluble in water (27.8 mg/ml). Atomoxetine hydrochloride is a hydrochloride form of the nervous system drug tomoxetine, an adrenal transmitter reuptake inhibitor, and Atomoxetine hydrochloride is used to treat attention deficit and hyperactivity disorder. Tomoxetine is a selective norepinephrine reuptake inhibitor (SNRI) with a structure similar to fluoxetine.
Action Pharmaceutical Raw Materials
Dosage for children and adolescents weighing less than 70 kg - Initially, the total daily dose of atomoxetine hydrochloride should be approximately 0.5 mg/kg, and after 3 days of the lowest dose, the dose should be increased to a total daily target dose of approximately 1.2 mg/kg, either as a single dose in the morning or divided equally into two doses in the morning and evening. Doses exceeding 1.2 mg/kg/day have not shown additional benefits.
For children and adolescents, the maximum daily dose should not exceed 1.4 mg/kg or 100 mg, whichever is smaller.
Dosage for children, adolescents, and adults weighing more than 70 kg - Initially, the total daily dose of atomoxetine hydrochloride should be 40 mg, and after 3 days of the lowest dose, the dose should be increased to a total daily target dose of approximately 80 mg, either as a single dose in the morning or divided equally into two doses in the morning and evening. If optimal therapeutic effect is still not achieved after continuing to use it for another 2 to 4 weeks, the total daily dose can be increased to a maximum of 100 mg. There is no data to support that higher doses will increase efficacy.
Functions of Atomoxetine hydrochloride powder
Functions and effect of Atomoxetine hydrochloride powder
1. Improve the core symptoms of ADHD
By selectively inhibiting norepinephrine reuptake, the concentration of neurotransmitters in the prefrontal cortex is increased, thereby enhancing attention, reducing hyperactivity and impulsive behavior.
Long-term use can help patients improve learning efficiency and social function.
2. Characteristics of the applicable population
Especially suitable for patients who are intolerant to central stimulants (such as methylphenidate) or are at risk of abuse.
It may be more advantageous for ADHD patients with comorbid tic disorders, anxiety or emotional problems.
Mechanism of action and advantages
3. Mechanism of action and advantages
Non-addictive, no risk of drug dependence, can be used for a long time.
The efficacy is stable, and 1-2 doses per day can maintain the effect throughout the day
Pharmacological Action of Atomoxetine hydrochloride powder.
Modern research believes that the pathogenesis of ADHD in children is a mild brain function defect caused by metabolic disorders of central catecholamine neurotransmitters dopamine (DA) and norepinephrine (NA). The exact mechanism of atomoxetine hydrochloride in treating ADHD in children is still unclear. It is currently believed that the therapeutic effect of this product is related to other selective inhibition of the reuptake effect of presynaptic amine pumps on NA, which can enhance the flipping effect of NA, thereby improving the symptoms of ADHD in children and indirectly promoting the completion of cognition and concentration of attention.
Production methodprocess of Atomoxetine hydrochloride powder
Atomoxetine hydrochloride was prepared using 3-methylamino-1-phenylpropyl alcohol as starting material, which was etherized with 2-fluoro-toluene, separated by L- (+) -mandelic acid, and finally dried hydrogen chloride as salt.
Why choose us?
HRK Factory
About Shipping
Pharmaceutical Intermediate manufacturers
©2023 Xi'an Henrikang Biotech Co., Ltd.,
Home
E-mail
Booking