Ofloxacin powder Raw Materials CAS 82419-36-1

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Uses and synthesis of Ofloxacin powder

​​Ofloxacin powder is a third-generation quinolone drug, also known as ofloxacin. On the basis of the fact that the basic skeleton of the molecular structure of quinolones is a nitrogen (hetero) bisexyclic structure, ofloxacin powder is replaced by fluorine at X-8 position, and it also includes a son ofloxacin. Developed by Dai-chi Pharmaceutical Co., LTD in 1982, Ofloxacin powder is a broad-spectrum antibacterial drug. Effective against bacteria, mycoplasma and some anaerobic bacteria, Ofloxacin is yellow or grayish yellow crystalline powder, odorless, bitter, slightly soluble in water, ethanolacetone, methanol, and easily soluble in glacial acetic acid. Ofloxacin is the levorotatory of ofloxacin, and its antibacterial activity in vitro is about twice that of ofloxacin. The mechanism of action is to prevent the synthesis and replication of bacterial DNA by inhibiting the activity of bacterial DNA rotation enzyme, which leads to bacterial death

​​​Applications/Functions of Ofloxacin powder

​​​Ofloxacin powder has the advantages of broad antibacterial spectrum, strong antibacterial activity, good bioavailability, safe and effective oral administration, low toxicity and no drug resistance. It has good antibacterial action against many kinds of gram-positive and gram-negative bacteria

​​​​​​Physicochemical Property of Ofloxacin powder

​​​From ethanol obtained colorless acicular crystal, odorless, bitter taste. Soluble in glacial acetic acid, more soluble in chloroform, less soluble in methanol, ethanol, acetone, chloroform or water, insoluble in ethyl acetate.

​​​Production methodprocess of Ofloxacin powder

​With 2, 3, 4-trifluoronitrobenzene as the starting material, after selective alkali hydrolysis, etherification, reduction, condensation, cyclization and hydrolysis with C2H5OCH=C(COOEt)2Chemicalbook or (CH3)2NCH=C(COOEt)2, and reaction with boron acetate, Ofloxacin powder was obtained by introducing N-methylpiperazine.

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