Nitrofurantoin powder Raw Materials CAS 67-20-9

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Uses and synthesis of Nitrofurantoin powder

Nitrofurantoin powder, also known as nitrofurantoin, nitrofurantoin, nitrofurantoin, chemical name 1-[[(5-nitro-2-furanyl)methylene]amino]-24-imidazolidinedioe, is a synthetic antimicrobial drug. The antibacterial spectrum is wide, and it has antibacterial effect on most gram-positive and negative bacteria, such as Staphylococcus aureus, Escherichia coli, Staphylococcus albus and streptococcus pyogenes. Clinical Nitrofurantoin is commonly used for urinary tract infections caused by sensitive bacteria, such as pyelonephritis and urinary tract infection. Cystitis and prostatitis.

Applications/Functions of Nitrofurantoin powder

• Nitrofurantoin powder is an excellent antibacterial drug. It can be absorbed quickly and completely after oral administration, and excreted quickly. The amount of nitrofurantoin powder can reach 40-50% in the urine. It is often used for the treatment of urinary tract infections caused by various sensitive bacteria and has a good effect on acute urinary tract infections caused by E. coli.
• Nitrofurantoin is an excellent antibiotic with a broad antibacterial spectrum and is suitable for urinary tract infections such as pyelonephritis, pyelitis and cystitis

Physicochemical Property of Nitrofurantoin powder

Nitrofurantoin is an orange-yellow acicular crystal. Melting point 270-272℃ (decomposition). The number of milligrams soluble in 100ml of the following solvents: water 19.0, 95% ethanol 51.0, acetone 510, DMF8000. Almost insoluble in chloroform. When the light becomes dark, odorless, bitter taste.

Production methodprocess of Nitrofurantoin powder

Acetone semicarbazone is produced by condensation of hydrazine hydrate and urea, and then condensation with acetone. Then, acetone hydantosyl urea is synthesized with ethyl chloroacetate ring, which is hydrolyzed and condensed with 5-nitrofurfural diacetate to produce Nitrofurantoin powder.

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